Epub 2012 Jul 7. COVID-19 is an emerging, rapidly evolving situation. 2005 Mar;11(2):81-4. doi: 10.1016/j.parkreldis.2004.07.012. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2007;68(6):1296-9. doi: 10.1016/j.mehy.2006.09.043. Yet, new guidelines and research suggest that statins’ benefits do not apply to everyone. 2017 May;31(5):335-343. doi: 10.1007/s40263-017-0422-3. Schang L, Koller D, Franke S, Sundmacher L. BMJ Open. Introduction: Statins have been widely used in clinical practice; however, the association between statin use and depression is complex as research findings have been mixed. 2019 Apr 9;10:200. doi: 10.3389/fpsyt.2019.00200. Statins provide protection against coronary and cerebrovascular diseases by decreasing cholesterol synthesis in the liver. Get the latest research from NIH: https://www.nih.gov/coronavirus. Introduction: Risk of Neuropsychiatric Adverse Effects of Lipid-Lowering Drugs: A Mendelian Randomization Study. Get the latest public health information from CDC: https://www.coronavirus.gov. CNS Drugs. 2018 Dec 1;21(12):1067-1075. doi: 10.1093/ijnp/pyy060. Please enable it to take advantage of the complete set of features! | Please enable it to take advantage of the complete set of features! Lieberman A, Lyons K, Levine J, Myerburg R. Parkinsonism Relat Disord. Current Therapeutic Approaches for Targeting Inflammation in Depression and Cardiovascular Disease. | Epub 2013 Sep 19. 2014 Sep;124:174-9. doi: 10.1016/j.pbb.2014.06.006. Med Hypotheses. NIH Statin medications also reduce inflammation. Expert opinion: Molero Y, Cipriani A, Larsson H, Lichtenstein P, D'Onofrio BM, Fazel S. Lancet Psychiatry. 2009 Mar;92(1):88-92. doi: 10.1016/j.pbb.2008.10.017. Alghamdi J, Matou-Nasri S, Alghamdi F, Alghamdi S, Alfadhel M, Padmanabhan S. Int J Neuropsychopharmacol. Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M; ASPREE Investigator Group. Statin medications also reduce inflammation. Zuzarte P, Duong A, Figueira ML, Costa-Vitali A, Scola G. Curr Drug Metab. Depression and Statin Drug Use From thousands of reports I have seen a strong association between statin drug use and affective disorders of all kinds. Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions. | Statins may enhance the proteolytic cleavage of proBDNF: implications for the treatment of depression. USA.gov. We know that cholesterol plays an important role in the serotonin system, so statins used to lower cholesterol may lead to the occurrence of depression. 2012 Sep;13(13):1901-9. doi: 10.1517/14656566.2012.706604. Epub 2008 Nov 5. Journal of Atherosclerosis and Thrombosis. Expert Opin Pharmacother. 2019;26:e000. Epub 2014 Jun 12. Eur J Cardiovasc Nurs. Statins have been widely used in clinical practice; however, the association between statin use and depression is complex as research findings have been mixed. Am J Cardiovasc Drugs. © Copyright 2018 Physicians Postgraduate Press, Inc. NLM | | Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress. Epub 2006 Nov 13. Diagnosis and management of statin intolerance. Since the pathophysiology of depression involves inflammation, statins could have a role in the treatment of mood disorders and might become a pharmacotherapy option for patients experiencing depression. Kelly RR, McDonald LT, Jensen NR, Sidles SJ, LaRue AC. For example, people with depression may have low cholesterol levels, but it has not been proved that lowering cholesterol with statin therapy causes depression. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. HHS Expert Opin Pharmacother. 2019 Jul;33(7):685-694. doi: 10.1007/s40263-019-00633-3. Areas covered: Comment on: the relationship between statins and depression: a review of the literature. | Nature Reviews Cardiology. Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats. eCollection 2019. HHS Alonso R, et al. However, the benefits of lowering total and LDL cholesterol have been demonstrated extensively, particularly in individuals with heart disease or at high risk of heart disease or strokes. Statins provide protection against coronary and cerebrovascular diseases by decreasing cholesterol synthesis in the liver. Statin therapy continues to help men lower their cholesterol levels, which can reduce their risk for heart attack or stroke. There is evidence suggesting an antidepressant effect when statins are adjunctively co-prescribed with antidepressant medicines. 2018;12:757. CNS Drugs. Statins, cholesterol, Co-enzyme Q10, and Parkinson's disease. Pharmacol Biochem Behav. Pleiotropic effects of statins: evidence against benefits beyond LDL-cholesterol lowering. 2018;19(8):674-687. doi: 10.2174/1389200219666180305143501. COVID-19 is an emerging, rapidly evolving situation. More research is required to confirm a potentially beneficial effect of prescribing statins to people with clinical depression. Since antidepressants work by changing neurotransmitter levels in the brain, it's possible for the chemicals to become imbalanced, which can lead to more severe mood symptoms, including thoughts of suicide. Since the pathophysiology of depression involves inflammation, statins could have a role in the treatment of mood disorders and might become a pharmacotherapy option for patients experiencing depression. 2019 Oct 16;9(10):e030272. Get the latest research from NIH: https://www.nih.gov/coronavirus. Clipboard, Search History, and several other advanced features are temporarily unavailable. Associations between statin use and suicidality, depression, anxiety, and seizures: a Swedish total-population cohort study. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. This article reviews i) cholesterol function in the brain, ii) how low cholesterol can cause depression, iii) a brief introduction of the serotonin system and how low cholesterol can disturb it, iv) neurosteroids and how they may lead to depression, and v) some direct evidence that statins can cause depression as well as contradicting evidence. Although this article stresses depression and its most extreme form, suicide, other affective manifestations include hostility, aggressiveness, rage, combativeness, accident proneness and special proneness for use of addictive substances. Front Psychiatry. CNS Drugs. Of the individual statins, simvastatin, by far the most widely used agent, was associated with a 7% reduction in the risk of developing depression, whereas atorvastatin was associated with an 11% increase in the risk of developing depression. The safety and effectiveness of statins as treatment for HIV-dyslipidemia: the evidence so far and the future challenges. 2020 Nov;7(11):982-990. doi: 10.1016/S2215-0366(20)30311-4. Mach F, et al. This site needs JavaScript to work properly. Renshaw PF, Parsegian A, Yang CK, Novero A, Yoon SJ, Lyoo IK, Cohen BM, Carlezon WA Jr. Pharmacol Biochem Behav. Köhler-Forsberg O, Gasse C, Berk M, Østergaard SD. 2010;10 Suppl 1:10-7. doi: 10.2165/1158822-S0-000000000-00000. This site needs JavaScript to work properly. We know that cholesterol plays an important role in the serotonin system, so statins used to lower cholesterol may lead to the occurrence of depression. 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